- Ph.D., University of Sydney, 2000
- The ways in which mitochondria support neurotransmission and influence synaptic plasticity
- The mechanisms responsible for pH homeostasis at synapses and their influence on synaptic plasticity
- The mechanisms supporting neurotransmission most vulnerable to aging
Rapid communication between cells is the basis for most of the functions of the nervous system, including sensory transduction, learning, memory, and locomotion. Most cells of the nervous system communicate at synapses, specialized sites at which closely opposed cells release chemicals known as neurotransmitters. Our laboratory investigates the release of neurotransmitters from nerve cells and factors that influence their release, such as mitochondria, pH, and age. We use electrophysiology and high-speed fluorescence imaging to construct a molecular, biophysical, and physiological understanding of neurotransmitter release. We conduct our studies primarily in the fruit fly because of its molecular genetic advantages but also conduct studies in mice to examine the effects of mitochondrial dysfunction and age on neurotransmitter release in a vertebrate nervous system.
- Wong, C.O., Chen, K., Lin, Y.Q., Chao, Y., Duraine, L., Lu, Z., Yoon, W.H., Sullivan, J.M., Broadhead, G.T., Sumner, C.J., Lloyd, T.E., Macleod, G.T., Bellen, H.J. and Venkatachalam, K. (2014). A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission. Neuron 84:764-777.
- Daniels, R.W., Rossano, A.J., Macleod, G.T. and Ganetzky, B. (2014). Expression of multiple transgenes from a single construct using viral 2A peptides in Drosophila. PLoS One 9:e100637.
- Grygoruk, A., Chen, A., Martin, C.A., Lawal, H.O., Fei, H., Gutierrez, G., Biedermann, T., Najibi, R., Hadi, R., Chouhan, A.K., Murphy, N.P., Schweizer, F.E., Macleod, G.T., Maidment, N.T. and Krantz, D.E. (2014). The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors. J Neurosci 34:6924-6937.
- Sakellariou, G.K., Davis, C.S., Shi, Y., Ivannikov, M.V., Zhang, Y., Vasilaki, A., Macleod, G.T., Richardson, A., Van Remmen, H., Jackson, M.J., McArdle, A. and Brooks, S.V. (2014). Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J 28:1666-1681.