Sarah L. Milton
- Ph.D., University of Miami Rosenstiel School of Marine and Atmospheric Science (RSMAS), 1994
- Animal models of anoxia and hypoxia tolerance
- Neuroprotective pathways in brain anoxia
- Reactive oxygen species and aging
My laboratory investigates physiological responses to environmental stress, primarily the effects of hypoxia and anoxia on the brain. While mammalian systems are highly sensitive to a lack of oxygen, certain animal models can withstand extended periods of complete anoxia (hours to days). Alternative animals models may thus allow us to discover novel therapeutic targets to preserve cell function in the absence of oxygen and upon reperfusion, an additional period of great stress.
- Sanchez, J.R., Milton, S.L., Corbit, K.C. and Buffenstein, R. (2015). Multifactorial processes to slowing the biological clock: Insights from a comparative approach. Experimental Gerentology pii: S0531-5565(15)30040-1. [Epub ahead of print].
- Ahles, N. and Milton, S. Mid-incubation relocation and embryonic survival in loggerhead sea turtle eggs. J Wildl Mangmt (In press).
- Kesaraju, S., Nayak, G., Prentice, H.M. and Milton, S.L. (2014). Upregulation of Hsp72 mediates anoxia/reoxygenation neuroprotection in the freshwater turtle via modulation of ROS. Brain Res 1582:247-256
- Sifuentes-Romero, I., Merchant-Larios, M., Milton, S.L, Moreno-Mendoza, N., Díaz-Hernández, V. and García-Gasca, A. (2013). RNAi-mediated gene silencing in a gonad organ culture to study sex determination mechanisms in sea turtle. Genes 4(2):293-305.